Advances in Cancer Research, Vol. 56 by GEORGE F. & GEORGE KLIEN (eds.) VANDE WOUDE



Meant for simple and medical researchers, immunologists, virologists and molecular biologists, this publication is a part of a chain which provides serious overviews on chosen elements of either melanoma study and the elemental underlying sciences.

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Because the first observations of Busch in 1866, the prospective use of warmth as a healing agent within the therapy of melanoma has been again and again topic to bursts of curiosity, virtually at all times by way of sessions of forget and skepticism. In 1963-1964, this challenge used to be back attacked through us either from the biochemical and from the scientific issues of view. Extra info for Advances in Cancer Research, Vol. 56

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B. (1989). Oncogene 4,549-558. , and. Leder, P. (1983). )34,779-787. , Nordan, R. , Owens, J. , Marcu, K. , and Mushinski, J. F. (1989). Oncogene 4,615-623. Beer, D. , Zweifel, K. , Simpson, D. , and Pitot, H. C. J. Cell. Physiol. 131, 29-35. Bentley, D. , and Groudine, M. Nafure (London) 321,702-706. Bentley, D. , and Groudine, M. Mol. Cell. B i d . 6, 3481-3489. Bentley, D. , Brown, W. , and Groudine, M. (1989). Genes Dev. 3, 1179- I 189. , and Adams, J. M. (1983). EMBOJ. 2, 2375-2383. , Jansen, H.

Loss of the block to transcription elongation in c-myc exon 1 5 . In the translocated alleles that maintain the first exon, a shift in promoter utilization to increased use of the minor upstream promoter, P I 6. Loss of DNase I hypersensitive sites in the nontranslocated c-myc allele, but maintainance of these same sites in the translocated allele 1. Abnormal Gene Topography in Burkitt’s Lymphoma A striking feature of BL cells is the consistent presence of reciprocal translocations between the c-myc locus on chromosome 8 and one of the immunoglobulin loci on chromosomes 14,2, or 22 (reviewed in Varmus, 1984; Rabbitts, 1985; Cole, 1986; Cory, 1986).

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