Advances in Breast Cancer Detection by E. L. Kitts Jr., J. Beutel, R. S. Holland, B. Blank (auth.),

go By E. L. Kitts Jr., J. Beutel, R. S. Holland, B. Blank (auth.), Professor Dr. Sam Brünner MD, PhD., Ass. Professor Dr. Bent Langfeldt MD, EDR. (eds.)

This booklet provides a synthesis of the newest advances within the early prognosis of breast melanoma. the knowledge on mammographic screening and follow-up trials from Scandinavian and American screening facilities is especially vital. The booklet additionally discusses cost/benefit difficulties, radiation hazard from screening mammography, technical diagnostic examinations equivalent to stereotactic biopsies and sonography, and non-palpable breast tumors. The contributions are from foreign experts and symbolize the most recent advances within the struggle opposed to breast melanoma.

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Consequences of Screening Finally, let us consider the consequences of screening: Screening for Breast Cancer 35 1. True negative: reassurance of no breast cancer 2. True positive: earlier diagnosis and treatment and better prognosis 3. False negative: false sense of security, delay in diagnosis and treatment, and worse prognosis 4. False positive: anxiety and tlle time, trouble, cost and risks of more tests, including unnecessary biopsies (McLelland 1984; Hall 1986) We must develop the expertise to keep false negatives and false positives at a minimum yet not wait for lesions to become obvious before initiating investigation.

Subsequent reports revealed similar results (Wolfe 1964; Witten and Thuber 1964; Stevens and Weigen 1966; Dowdy et al. 1971). The screening project of the Health Insurance Plan (HIP) of Greater New York from 1963 to 1966 was a landmark and the first randomized trial to reveal significant reduction in mortality from breast cancer in women screened by means of physical examination and mammography. However, until more recent long-term follow-up, this applied only to women age 50 and over (Shapiro 1977; Shapiro et al.

In: Boice JD Jr, Fraumeni JF Jr (eds) Radiation carcinogenesis: epidemiology and biological significance. Raven, New York, pp 119-129 Kbpans DB, Meyer JE, Sadowsky N:-(1984) Breast imaging. N Engl J Med 310: 960-967 Martin J, Moskowitz M, Milbrath JR (1979) Breast cancer missed by mammography. AIR 132: 737-739 McFarlane C, Sturgis MC, Fetterman FS (1955) Results of an experiment in the control of cancer of the female pelvic organs and report of a fifteen-year research. Am JObst Gynecol 69: 294 McLelland R (1978) Mammography in the detection, diagnosis and management of carcinoma of the breast.

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