Advances in Breast Cancer Detection by E. L. Kitts Jr., J. Beutel, R. S. Holland, B. Blank (auth.),

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go By E. L. Kitts Jr., J. Beutel, R. S. Holland, B. Blank (auth.), Professor Dr. Sam Brünner MD, PhD., Ass. Professor Dr. Bent Langfeldt MD, EDR. (eds.)

This booklet provides a synthesis of the newest advances within the early prognosis of breast melanoma. the knowledge on mammographic screening and follow-up trials from Scandinavian and American screening facilities is especially vital. The booklet additionally discusses cost/benefit difficulties, radiation hazard from screening mammography, technical diagnostic examinations equivalent to stereotactic biopsies and sonography, and non-palpable breast tumors. The contributions are from foreign experts and symbolize the most recent advances within the struggle opposed to breast melanoma.

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Consequences of Screening Finally, let us consider the consequences of screening: Screening for Breast Cancer 35 1. True negative: reassurance of no breast cancer 2. True positive: earlier diagnosis and treatment and better prognosis 3. False negative: false sense of security, delay in diagnosis and treatment, and worse prognosis 4. False positive: anxiety and tlle time, trouble, cost and risks of more tests, including unnecessary biopsies (McLelland 1984; Hall 1986) We must develop the expertise to keep false negatives and false positives at a minimum yet not wait for lesions to become obvious before initiating investigation.

Subsequent reports revealed similar results (Wolfe 1964; Witten and Thuber 1964; Stevens and Weigen 1966; Dowdy et al. 1971). The screening project of the Health Insurance Plan (HIP) of Greater New York from 1963 to 1966 was a landmark and the first randomized trial to reveal significant reduction in mortality from breast cancer in women screened by means of physical examination and mammography. However, until more recent long-term follow-up, this applied only to women age 50 and over (Shapiro 1977; Shapiro et al.

In: Boice JD Jr, Fraumeni JF Jr (eds) Radiation carcinogenesis: epidemiology and biological significance. Raven, New York, pp 119-129 Kbpans DB, Meyer JE, Sadowsky N:-(1984) Breast imaging. N Engl J Med 310: 960-967 Martin J, Moskowitz M, Milbrath JR (1979) Breast cancer missed by mammography. AIR 132: 737-739 McFarlane C, Sturgis MC, Fetterman FS (1955) Results of an experiment in the control of cancer of the female pelvic organs and report of a fifteen-year research. Am JObst Gynecol 69: 294 McLelland R (1978) Mammography in the detection, diagnosis and management of carcinoma of the breast.

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